SPIKES
func
-logK
i
Values
Competitive
Antagonist
-logK
i
Value
M
1
M
2
M
3
M
4
M
5
Pirenzepine
8.2
6.5
6.9
7.4
7.2
Methoctramine
6.7
7.7
6.0
7.0
6.3
Darifenacin
7.8
7.0
8.8
7.7
8.0
MT-3
6.7
5.9
6.0
8.1
6.0
S-Secoverine
8.0
7.9
7.7
7.7
6.5
Solifenacin
7.6
6.8
7.9
7.0
7.5
DAU-5884
8.9
7.1
8.9
8.5
8.1
PD102807
5.8
5.8
6.4
7.6
4.7